AUTHOR=Chen Yvonne , Mateski Julia , Gerace Linda , Wheeler Jonathan , Burl Jan , Prakash Bhavna , Svedin Cherie , Amrick Rebecca , Adams Brian D. 

TITLE=Non-coding RNAs and neuroinflammation: implications for neurological disorders

JOURNAL=Experimental Biology and Medicine

VOLUME=Volume 249 - 2024

YEAR=2024

URL=https://www.ebm-journal.org/journals/experimental-biology-and-medicine/articles/10.3389/ebm.2024.10120

DOI=10.3389/ebm.2024.10120

ISSN=1535-3699

ABSTRACT=miRNAs regulate cell-signaling regulatory networks at the post-transcriptional level, resulting in controlled cellular development responsive to extracellular stimuli. miRNAs also control the expression of genetic outputs during neuronal development. This neuronal cellular process is tightly regulated and tuned by acute and/or chronic inflammatory cues that, when disrupted, result in the onset of various neurological disorders. This review is an attempt to highlight miRNAs that modulate the neuroinflammatory state within the central nervous system and to elucidate the underlying mechanisms that promote or abrogate excessive inflammatory signaling as these biomolecules may become new therapeutic targets in the treatment of chronic neurological disorders such as epilepsy, ALS, Parkinson's, Alzheimer's, and Huntington's.