This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
A Corrigendum on A double-edged effect of hypoxia on astrocyte-derived exosome releases by Tseng YJ, Huang H-J, Lin C-H and Lin AM-Y (2025). Exp. Biol. Med. 250:10559. doi: 10.3389/ebm.2025.10559hypoxic preconditioningdouble-edged roleexosomesheminCTX-TNA2
In the original article, there was a mistake in Figure 6 as published. The error was due to the inadvertent insertion of an incorrect version of the figure during the final submission process. Specifically, the published figure mistakenly displayed HO-1 (A, B) and GPX4 (C, D), instead of the correct picture, which should show GPX4 (A, B) and active-caspase 3 (C, D), as measured by Western blot assay. The corrected Figure 6 appears below.
Differential effects of 2H/6R exosomes and 12H/24R exosomes on hemin-induced programmed cell death in primary cultured cortical neurons. (A,C) Primary cultured cortical neurons were treated with hemin (30 μM) plus 2H/6R exosomes obtained from 1 × 106 CTX-TNA2 cells (as 1 fold) for 16 h (B,D) Primary cultured cortical neurons were treated with hemin (30 μM) plus 12H/24R exosomes (1 fold and 3 folds) for 16 h. Western blot assay was employed to measure GPX4 (A,B) and active-caspase 3 (C,D). Each lane contained 30 μg protein for all experiments. Graphs show statistic results from relative optical density of bands on the blots. Values are the mean ± S.E.M. (n = 3/each group). *, p < 0.05 statistically significant in the hemin groups compared with the control groups; #, P < 0.05 in hemin plus exosomes compared with hemin alone by one-way ANOVA followed by the LSD test as post hoc method.
Panels A to D display Western blot analyses and corresponding bar graphs showing relative protein density. Panels A and B show GPX4 levels with hemin and exosome treatments preconditioned under different conditions. Panels C and D show α-Caspase 3 levels under similar treatments. β-Actin is used as a loading control. Asterisks indicate significant differences between control group and the hemin group, while hash marks indicate significant differences between hemin plus exosome group and hemin alone group.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.